(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

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Chemical Name:(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate
CAS No.:1197420-26-0
Molecular Formula:C₃₄H₄₆ClN₂O₇PSSi₂
Molecular Weight:749.412
Hs Code.:

Synonyms:(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

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Chemical Property of (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

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Technology Process of (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

There total 11 articles about (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

: 1197420-05-5
(R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

: 121373-20-4
N,N-Diisopropyl-bis<2-(trimethylsilyl)ethyl>phosphoramidite

: 1197420-26-0
(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

Guidance literature:: (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one; N,N-Diisopropyl-bis<2-(trimethylsilyl)ethyl>phosphoramidite; With 1,2,4-Triazole; In dichloromethane; at 20 - 40 ℃; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; water; at -4 - 5 ℃;

With sodium metabisulfite; water; In dichloromethane; at 10 - 18 ℃; for 0.533333 - 0.583333h; Cooling;

Reference yield: 95.3%

: C₃₄H₄₆ClN₂O₆PSSi₂

: 1197420-26-0
(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

Guidance literature:: With dihydrogen peroxide; In dichloromethane; at -3 - 5 ℃; for 2.25h;
DOI:10.1021/jm500026w

Reference yield:

: 1197420-16-8
1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanone

: 1197420-26-0
(R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / ethanol / 0.83 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 10 °C / Inert atmosphere

2.1: Chiralpak AD-H column / acetonitrile; isopropyl alcohol / 35 °C / Supercritical conditions; Resolution of racemate

3.1: hydrogen; 5%-palladium/activated carbon / ethanol / 2.5 h / 20 °C / 760.05 Torr

4.1: phenol / 0.5 h / 130 °C

5.1: 1,2,4-Triazole / dichloromethane / 18 h / 20 °C / Inert atmosphere; Reflux

6.1: dihydrogen peroxide / dichloromethane / 2.25 h / -3 - 5 °C

With 1,2,4-Triazole; sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; In ethanol; dichloromethane; isopropyl alcohol; acetonitrile; phenol;
DOI:10.1021/jm500026w