2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

Base Information

Chemical Name:2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine
CAS No.:1350880-62-4
Molecular Formula:C₂₁H₂₁F₄N₅
Molecular Weight:419.425
Hs Code.:

Synonyms:2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

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Chemical Property of 2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

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Technology Process of 2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

There total 6 articles about 2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460-40-2
3,3,3-trifluoropropanal

: 1350881-12-7
2-[3-(4-fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazoI-1-yl]pyrimidine

: 1350880-62-4
2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 71381-75-4,88495-54-9,84358-12-3
N-(tert-butyloxycarbonyl)nipecotic acid

: 1350880-62-4
2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: methylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C

2.2: 20 °C

3.1: hydrazine / ethanol / 3 h / 75 °C

4.1: caesium carbonate; 1,10-Phenanthroline / copper(l) iodide / toluene / 4 h / 120 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

6.1: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane; tetrahydrofuran / 20 °C

With hydrogenchloride; dmap; 1,10-Phenanthroline; methylmagnesium bromide; sodium cyanoborohydride; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; hydrazine; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 189442-78-2
(±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 1350880-62-4
2-{3-(4-fluorophenyl)-5-[1-(3,3,3-trifluoropropyl)piperidin-3-yl]-1H-pyrazol-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: methylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C

1.2: 20 °C

2.1: hydrazine / ethanol / 3 h / 75 °C

3.1: caesium carbonate; 1,10-Phenanthroline / copper(l) iodide / toluene / 4 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

5.1: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane; tetrahydrofuran / 20 °C

With hydrogenchloride; 1,10-Phenanthroline; methylmagnesium bromide; sodium cyanoborohydride; caesium carbonate; acetic acid; hydrazine; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;