O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine

Base Information

• Chemical Name: O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine
• CAS No.: 119255-40-2
• Molecular Formula: C₂₆H₂₈NO₆PS₂
• Molecular Weight: 545.617
• Mol file: 119255-40-2.mol

Synonyms:O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine

Chemical Property of O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine

There total 6 articles about O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-3-[4-(Bis-phenylsulfanyl-phosphoryloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid di-p-tolylmethyl ester (134166-86-2) → O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine (119255-40-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4039(00)79664-X

Reference yield:

Boc-Tyr-OH (3978-80-1) → O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine (119255-40-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / 40percent peracetic acid, I₂ / CH₂Cl₂ / 0 °C

2: 80 percent / isodurenedisulfonyl chloride, 1H tetrazole, pyridine

3: 90 percent / TFA / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; 1H-tetrazole; peracetic acid; iodine; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)79664-X

Reference yield:

(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid di-p-tolylmethyl ester (134166-85-1) → O-(S,S-Diphenyl)phosphorodithioyl Boc-tyrosine (119255-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / isodurenedisulfonyl chloride, 1H tetrazole, pyridine

2: 90 percent / TFA / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; 1H-tetrazole; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)79664-X

upstream raw materials:

(S)-3-[4-(Bis-phenylsulfanyl-phosphoryloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid di-p-tolylmethyl ester

(S)-3-[4-(Bis-phenylsulfanyl-phosphoryloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid 9,10-dioxo-9,10-dihydro-anthracen-2-ylmethyl ester

(S,S')-diphenylphosphorodithioate

N^α-(tert-butoxycarbonyl)tyrosine anthraquinon-2-ylmethylester