methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

Base Information

Chemical Name:methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate
CAS No.:1373551-38-2
Molecular Formula:C₃₀H₃₄O₆
Molecular Weight:490.596
Hs Code.:

Synonyms:methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

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Chemical Property of methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

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Technology Process of methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

There total 4 articles about methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1000414-38-9,1234474-58-8
methyl ((3S)-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetate

: 805250-51-5
[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methanol

: 1373551-38-2
methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm300170m

Reference yield:

: 805250-31-1
4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

: 1373551-38-2
methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium tetrahydroborate / 20 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 h / 80 °C / Inert atmosphere

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; tributylphosphine; potassium carbonate; potassium iodide; 1,1'-azodicarbonyl-dipiperidine; In N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jm300170m

Reference yield:

: 805250-17-3,1234474-58-8
(6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

: 1373551-38-2
methyl [(3S)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: CHIRALPAK AD column / ethanol; hexane / Resolution of racemate

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In ethanol; hexane; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jm300170m