3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Base Information

Chemical Name:3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea
CAS No.:1403479-04-8
Molecular Formula:C₄₄H₅₆N₄O₆
Molecular Weight:736.952
Hs Code.:

3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Synonyms:3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

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Chemical Property of 3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

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Technology Process of 3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

There total 4 articles about 3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1353557-67-1
C₃₇H₅₀N₄O₆

: 100-52-7
benzaldehyde

: 1403479-04-8
3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: C₃₇H₅₀N₄O₆; benzaldehyde; With magnesium sulfate; In dichloromethane; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 103-71-9
phenyl isocyanate

: 1403479-04-8
3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 16 h / Inert atmosphere

2.1: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere; Cooling with ice

2.2: 0.5 h

3.1: magnesium sulfate / dichloromethane / 1 h / Inert atmosphere

3.2: 4 h / 20 °C

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; magnesium sulfate; In dichloromethane;

Reference yield:

: 1333331-66-0
tert-butyl (((2S,8R,9R)-14-amino-11-((S)-1-((4-methoxybenzyloxy)prop-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-ecahydrobenzo[b][1,9,5]dioxaazacyclotetradec-8-yl)methyl)-methyl)carbamate

: 1403479-04-8
3-[(2S,8R,9R)-8-{[benzyl(methyl)amino]methyl}-11-[(2S)-1-[(4-methoxyphenyl)methoxy]propan-2-yl]-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-14-yl]-1-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 16 h / Inert atmosphere

2.1: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere; Cooling with ice

2.2: 0.5 h

3.1: magnesium sulfate / dichloromethane / 1 h / Inert atmosphere

3.2: 4 h / 20 °C

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; magnesium sulfate; In dichloromethane;