(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester
CAS No.:183145-81-5
Molecular Formula:C₁₈H₂₃NO₆
Molecular Weight:349.384
Hs Code.:

Synonyms:(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

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Chemical Property of (E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

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Technology Process of (E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

There total 8 articles about (E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 77-78-1
dimethyl sulfate

: 183145-79-1
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

: 183145-81-5
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

Guidance literature:: With potassium carbonate; In acetone; for 4.5h; Heating;

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 183145-81-5
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / tetrahydrofuran / 18 h / 48 °C

2: 100 percent / p-toluensulfonic acid hydrate / CH₂Cl₂ / 1.67 h / Ambient temperature

3: 1.) BuLi / 1.) THF, hexane, -30 deg C, 70 min, 2.) THF, hexane, -20 deg C, 30 min

4: 93 percent / 0.2N aq. HCl / ethanol / 1 h / Heating

5: 74 percent / MnO₂ / diethyl ether / 96 h / Ambient temperature

6: 100 percent / piperidine, pyridine / 1 h / Ambient temperature

7: 94 percent / K₂CO₃ / acetone / 4.5 h / Heating

With piperidine; pyridine; hydrogenchloride; manganese(IV) oxide; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 183145-81-5
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / tetrahydrofuran / 18 h / 48 °C

2: 100 percent / p-toluensulfonic acid hydrate / CH₂Cl₂ / 1.67 h / Ambient temperature

3: 1.) BuLi / 1.) THF, hexane, -30 deg C, 70 min, 2.) THF, hexane, -20 deg C, 30 min

4: 93 percent / 0.2N aq. HCl / ethanol / 1 h / Heating

5: 74 percent / MnO₂ / diethyl ether / 96 h / Ambient temperature

6: 100 percent / piperidine, pyridine / 1 h / Ambient temperature

7: 94 percent / K₂CO₃ / acetone / 4.5 h / Heating

With piperidine; pyridine; hydrogenchloride; manganese(IV) oxide; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone;