(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

Base Information

Chemical Name:(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid
CAS No.:183145-79-1
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:

Synonyms:(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

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Chemical Property of (E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

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Technology Process of (E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

There total 7 articles about (E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 141-82-2
malonic acid

: 183145-78-0
[tert-Butoxycarbonyl-(2-formyl-phenyl)-amino]-acetic acid methyl ester

: 183145-79-1
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

Guidance literature:: With piperidine; pyridine; for 1h; Ambient temperature;

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 183145-79-1
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / tetrahydrofuran / 18 h / 48 °C

2: 100 percent / p-toluensulfonic acid hydrate / CH₂Cl₂ / 1.67 h / Ambient temperature

3: 1.) BuLi / 1.) THF, hexane, -30 deg C, 70 min, 2.) THF, hexane, -20 deg C, 30 min

4: 93 percent / 0.2N aq. HCl / ethanol / 1 h / Heating

5: 74 percent / MnO₂ / diethyl ether / 96 h / Ambient temperature

6: 100 percent / piperidine, pyridine / 1 h / Ambient temperature

With piperidine; pyridine; hydrogenchloride; manganese(IV) oxide; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 183145-79-1
(E)-3-[2-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-phenyl]-acrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / tetrahydrofuran / 18 h / 48 °C

2: 100 percent / p-toluensulfonic acid hydrate / CH₂Cl₂ / 1.67 h / Ambient temperature

3: 1.) BuLi / 1.) THF, hexane, -30 deg C, 70 min, 2.) THF, hexane, -20 deg C, 30 min

4: 93 percent / 0.2N aq. HCl / ethanol / 1 h / Heating

5: 74 percent / MnO₂ / diethyl ether / 96 h / Ambient temperature

6: 100 percent / piperidine, pyridine / 1 h / Ambient temperature

With piperidine; pyridine; hydrogenchloride; manganese(IV) oxide; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;