(-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

Base Information

• Chemical Name: (-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one
• CAS No.: 321835-86-3
• Molecular Formula: C₃₄H₄₆N₄O₆S₂
• Molecular Weight: 678.831

Synonyms:(-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

Chemical Property of (-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

Chemical Property:

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Technology Process of (-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

There total 1 articles about (-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

[1,1,2,2,3,3,4,4-2H8]butane-1,4-diyl bis(methanesulfonate) (116653-28-2) + (-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide (321835-85-2) → (-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H8]-1,5,9,13-tetraazacycloheptadecan-6-one (321835-86-3)

Guidance literature:

(-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide; With caesium carbonate; In N,N-dimethyl-formamide; at 62 ℃; for 0.5h;

[1,1,2,2,3,3,4,4-2H₈]butane-1,4-diyl bis(methanesulfonate); In N,N-dimethyl-formamide; at 55 ℃; for 48h;

DOI:10.1002/1522-2675(20001108)83:11<2953::AID-HLCA2953>3.0.CO;2-I

Reference yield: 80.0%

(-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H8]-1,5,9,13-tetraazacycloheptadecan-6-one (321835-86-3) → (-)-(8S)-(4-methoxyphenyl)[14,14,15,15,16,16,17,17-2H8]-1,5,9,13-tetraazacycloheptadecan-6-one (321835-87-4)

Guidance literature:

Electrochemical reaction;

DOI:10.1002/1522-2675(20001108)83:11<2953::AID-HLCA2953>3.0.CO;2-I

Reference yield:

(-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H8]-1,5,9,13-tetraazacycloheptadecan-6-one (321835-86-3) → (-)-(8S)-8-(4-methoxyphenyl)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl][14,14,15,15,16,16,17,17-2H8]-1,5,9,13-tetraazacycloheptadecan-6-one (321835-90-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / Electrochemical reaction

2: 92 percent / methanol; H₂O

3: 65 percent / CH₂Cl₂; triethylamine / 2 h / 0 °C

4: 98 percent / NH₂OH*HCl / aq. HCl / 1 h / 70 °C

With hydroxylamine hydrochloride; In hydrogenchloride; methanol; dichloromethane; water; triethylamine;

DOI:10.1002/1522-2675(20001108)83:11<2953::AID-HLCA2953>3.0.CO;2-I

upstream raw materials:

[1,1,2,2,3,3,4,4-2H₈]butane-1,4-diyl bis(methanesulfonate)

(-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide

Downstream raw materials:

(-)-(8S)-(4-methoxyphenyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

(+)-(2S)-2-(4-methoxyphenyl)[10,10,11,11,12,12,13,13-2H₈]-1,5,9,14-tetraazabicyclo[12.3.1]octadecan-4-one

(-)-(8S)-8-(4-methoxyphenyl)-1-[(E)-3-(4-methoxyphenyl)prop-2-enoyl][14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

(+)-(2S)-2-(4-methoxyphenyl)-9-[(E)-3-(4-methoxyphenyl)prop-2-enoyl][10,10,11,11,12,12,13,13-2H₈]-1,5,9,14-tetraazabicyclo[12.3.1]octadecan-4-one

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