116653-28-2 Usage
Uses
Used in Pharmaceutical Industry:
BUSULFAN-D8 (TETRAMETHYLENE-D8) is used as an internal standard for the quantification of busulfan in pharmaceutical research and development. This application is crucial for ensuring the accurate measurement and dosing of busulfan, an alkylating antineoplastic agent, in the treatment of various cancers.
Used in Cancer Treatment:
BUSULFAN-D8 (TETRAMETHYLENE-D8) is used as an alkylating agent with antileukemic activity. It plays a significant role in the treatment of leukemia and other malignancies by forming intraand interstrand crosslinks on DNA, which leads to the disruption of cancer cell replication and growth.
Used in Research and Development:
In the field of research and development, BUSULFAN-D8 (TETRAMETHYLENE-D8) is employed as a valuable tool for studying the mechanisms of action, pharmacokinetics, and pharmacodynamics of busulfan. This helps in the development of new therapeutic strategies and the improvement of existing treatments for cancer patients.
Used in Quality Control and Analytical Testing:
BUSULFAN-D8 (TETRAMETHYLENE-D8) is utilized as a reference material in quality control and analytical testing of busulfan-containing products. It ensures the reliability and accuracy of test results, which is essential for maintaining the safety and efficacy of these medications.
Used in Drug Development and Toxicology Studies:
In drug development and toxicology studies, BUSULFAN-D8 (TETRAMETHYLENE-D8) serves as a valuable tool for understanding the metabolic pathways, potential side effects, and toxicological profiles of busulfan. This information is crucial for the design of safer and more effective cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 116653-28-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,6,5 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 116653-28:
(8*1)+(7*1)+(6*6)+(5*6)+(4*5)+(3*3)+(2*2)+(1*8)=122
122 % 10 = 2
So 116653-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3/i3D2,4D2,5D2,6D2
116653-28-2Relevant academic research and scientific papers
The asymmetric synthesis of the [D8]-labeled (-)-(S)-dihydroxyverbacine, the terminal precursor in the biogenesis of the macrobicyclic spermine alkaloids aphelandrine and orantine
Nezbedova, Lenka,Drandarov, Konstantin,Werner, Christa,Hesse, Manfred
, p. 2953 - 2960 (2007/10/03)
The asymmetric synthesis of the unlabeled and [D8]-labeled terminal precursors, 4 ((-)-(S)-dihydroxyverbacine) and 19, respectively, in the biogenesis of the spermine alkaloids aphelandrine (5) and orantine (6), respectively, is described. A pa
