methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate

Base Information

Chemical Name:methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate
CAS No.:1365802-43-2
Molecular Formula:C₂₂H₁₅F₃N₄O₂
Molecular Weight:424.382
Hs Code.:

Synonyms:methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate

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Technology Process of methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate

There total 2 articles about methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1365803-37-7
8-chloro-N-(3-(trifluoromethyl)phenyl)pyrido[2,3-d]pyridazin-5-amine

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1365802-43-2
methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 90 ℃; for 16h; Inert atmosphere; sealed tube;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 703-33-3
5,8-Dichloropyrido<2,3-d>pyridazine

: 1365802-43-2
methyl 4-(5-{[3-(trifluoromethyl)phenyl]amino}pyrido[2,3-d]pyridazin-8-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 0.38 h / 100 °C / sealed tube

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere; sealed tube

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;