N₆-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine

Base Information

• Chemical Name: N₆-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine
• CAS No.: 1392420-04-0
• Molecular Formula: C₄₀H₄₆N₅O₁₀P
• Molecular Weight: 787.806

Synonyms:N₆-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine

Chemical Property of N₆-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₆-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine

There total 3 articles about N₆-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

diethylphosphonoacetic acid (3095-95-2) + 6-N-(4,4'-dimethoxytrityl)-2',3'-O-isopropylideneadenosine (439097-83-3) → N6-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine (1392420-04-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.04.045

Reference yield:

2',3'-isopropylidene adenosine (362-75-4) → N6-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine (1392420-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; chloro-trimethyl-silane / 1 h

1.2: 1.5 h

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; chloro-trimethyl-silane; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.ejmech.2012.04.045

Reference yield:

adenosine (58-61-7) → N6-(4,4'-dimethoxytrityl)-2',3'-isopropylidene-5'-O-[(diethylphosphono)acetyl]-adenosine (1392420-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: perchloric acid / 2 h / Inert atmosphere

2.1: pyridine; chloro-trimethyl-silane / 1 h

2.2: 1.5 h

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; chloro-trimethyl-silane; perchloric acid; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.ejmech.2012.04.045

upstream raw materials:

diethylphosphonoacetic acid

6-N-(4,4'-dimethoxytrityl)-2',3'-O-isopropylideneadenosine

2',3'-isopropylidene adenosine

adenosine

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