N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

Base Information

Chemical Name:N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide
CAS No.:796089-76-4
Molecular Formula:C₂₅H₃₃N₅O₇
Molecular Weight:515.566
Hs Code.:

<i>N</i>-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-<i>N</i>'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

Synonyms:N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

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Chemical Property of N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

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Technology Process of N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

There total 3 articles about N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {2-[2-(2-{3-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethylcarbamoyl]-propionylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester

: 796089-76-4
N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ja0461163

Reference yield:

: 2440-62-2
N-(3-carboxypropionyl)-L-phenylalanine p-nitroanilide

: 796089-76-4
N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole; diisopropylethylamine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide; CH₂Cl₂ / 0.08 h / 0 °C

1.2: dimethylformamide; CH₂Cl₂ / 0 - 4 °C

2.1: TFA / CH₂Cl₂ / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0461163

Reference yield:

: 153086-78-3
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

: 796089-76-4
N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-N'-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-succinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole; diisopropylethylamine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide; CH₂Cl₂ / 0.08 h / 0 °C

1.2: dimethylformamide; CH₂Cl₂ / 0 - 4 °C

2.1: TFA / CH₂Cl₂ / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0461163