1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One

Base Information

Chemical Name:1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One
CAS No.:120889-04-5
Molecular Formula:C13H11 N3 O
Molecular Weight:225.25
Hs Code.:
DSSTox Substance ID:DTXSID90399990
Nikkaji Number:J917.520B
Wikidata:Q27451023
ChEMBL ID:CHEMBL1956634
Mol file:120889-04-5.mol

Synonyms:120889-04-5;914918-69-7;2-Hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine;1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One;1-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-one;1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ol;2H-Imidazo[4,5-b]pyridin-2-one,1,3-dihydro-1-methyl-6-phenyl-;CHEMBL1956634;3uwk;starbld0018835;SCHEMBL2207001;DTXSID90399990;BDBM50365390;AKOS025149629;AKOS030253167;FT-0669305;FT-0669839;FT-0669842;J-004407;Q27451023;1-methyl-6-phenyl-1H,2H,3H-imidazo[4,5-b]pyridin-2-one;0DF

Suppliers and Price of 1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
25mg
$ 215.00

TRC
2-Hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
250mg
$ 1695.00

Medical Isotopes, Inc.
2-Hydroxy-1-methyl-6-phenylimidazo[4,5-β]pyridine
25 mg
$ 845.00

American Custom Chemicals Corporation
2-HYDROXY-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE 95.00%
250MG
$ 1732.50

American Custom Chemicals Corporation
2-HYDROXY-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE 95.00%
25MG
$ 721.88

Total 6 raw suppliers

Chemical Property of 1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One

Chemical Property:

Melting Point:260-263°C
Refractive Index:1.622
PSA：50.94000
Density:1.247g/cm³
LogP:2.34090
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:225.090211983
Heavy Atom Count:17
Complexity:301

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(NC1=O)N=CC(=C2)C3=CC=CC=C3
Uses 2-Hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine (cas# 120889-04-5) is a compound useful in organic synthesis.

Technology Process of 1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One

There total 7 articles about 1-Methyl-6-Phenyl-1,3-Dihydro-2h-Imidazo[4,5-B]pyridin-2-One which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1190594-65-0
1-methyl-4-amino-imidazol-2-one

: 4432-64-8
hydroxymethylenephenylacetaldehyde

: 120889-04-5
2-Hydroxy-PhIP

Guidance literature:: With acetic acid; for 2h; Reflux;
DOI:10.1016/j.tetlet.2009.07.091

Reference yield:

: 1355153-73-9
1-methyl-6-phenyl-3-trityl-1H-imidazo[4,5-b]pyridin-2(3H)-one

: 120889-04-5
2-Hydroxy-PhIP

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm201349f

Reference yield:

: 6-bromo-3-methyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one

: 120889-04-5
2-Hydroxy-PhIP

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tricyclohexylphosphine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; trifluoroacetic acid; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm201349f