(2S,3S)-2--1-phenylhex-5-yn-3-ol

Base Information

Chemical Name:(2S,3S)-2--1-phenylhex-5-yn-3-ol
CAS No.:152170-20-2
Molecular Formula:C₂₅H₂₃NO
Molecular Weight:353.464
Hs Code.:

(2S,3S)-2-<N-(diphenylmethylene)amino>-1-phenylhex-5-yn-3-ol

Synonyms:(2S,3S)-2--1-phenylhex-5-yn-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2--1-phenylhex-5-yn-3-ol

Chemical Property:

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Technology Process of (2S,3S)-2--1-phenylhex-5-yn-3-ol

There total 1 articles about (2S,3S)-2--1-phenylhex-5-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18295-60-8
allenylmagnesium bromide

: 120238-42-8,131472-74-7
methyl (S)-2-(diphenylmethylideneamino)-3-phenylpropanoate

: (2S,3R)-2--1-phenylhex-5-yn-3-ol

: 152170-20-2
(2S,3S)-2--1-phenylhex-5-yn-3-ol

Guidance literature:: With triisobutylaluminum; diisobutylaluminium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, toluene, from -73 deg C to -68 deg C, 2.) CH₂Cl₂, toluene, ether, a) -73 deg C, 10 h, b) from -73 deg C to 15 deg C, 4 h;

Reference yield:

: 152170-20-2
(2S,3S)-2--1-phenylhex-5-yn-3-ol

: 125356-66-3,119463-16-0
(+)-preussin

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) KH / 1.) THF, 25 deg C , 2 h, 2.) THF, from 0 deg C to 25 deg C, 1 h

2: aq. H₂C₂O₄ / methanol; tetrahydrofuran / 3 h / 25 °C

3: 1.) CpTi(CH₃)2Cl / 1.) THF, Et₂O, 25 deg C, 2 h, 2.) THF, Et₂O, 25 deg C, 2 h

4: 2.) NaBH₃CN / 1.) CH₂Cl₂, 25 deg C, 2 h, 2.) CH₂Cl₂, MeOH, 25 deg C, 2 h

5: Mg, CH₃OH / 5 h / 25 °C

6: K, t-BuOH, HMPA / diethyl ether; toluene / 4 h / 25 °C

7: H₂ / 10percent Pd/C / ethanol / 2068.6 Torr

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; chlorodimethylcyclopentadienyltitanium(IV); hydrogen; oxalic acid; potassium hydride; sodium cyanoborohydride; magnesium; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; toluene;

Reference yield:

: 152170-20-2
(2S,3S)-2--1-phenylhex-5-yn-3-ol

: 152170-23-5
(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KH / 1.) THF, 25 deg C , 2 h, 2.) THF, from 0 deg C to 25 deg C, 1 h

2: aq. H₂C₂O₄ / methanol; tetrahydrofuran / 3 h / 25 °C

3: 1.) CpTi(CH₃)2Cl / 1.) THF, Et₂O, 25 deg C, 2 h, 2.) THF, Et₂O, 25 deg C, 2 h

4: 2.) NaBH₃CN / 1.) CH₂Cl₂, 25 deg C, 2 h, 2.) CH₂Cl₂, MeOH, 25 deg C, 2 h

With chlorodimethylcyclopentadienyltitanium(IV); oxalic acid; potassium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol;