(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

Base Information

Chemical Name:(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine
CAS No.:152170-23-5
Molecular Formula:C₂₉H₃₈N₂O
Molecular Weight:430.634
Hs Code.:

Synonyms:(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

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Chemical Property of (2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

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Technology Process of (2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

There total 8 articles about (2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 152170-23-5
(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KH / 1.) THF, 25 deg C , 2 h, 2.) THF, from 0 deg C to 25 deg C, 1 h

2: aq. H₂C₂O₄ / methanol; tetrahydrofuran / 3 h / 25 °C

3: 1.) CpTi(CH₃)2Cl / 1.) THF, Et₂O, 25 deg C, 2 h, 2.) THF, Et₂O, 25 deg C, 2 h

4: 2.) NaBH₃CN / 1.) CH₂Cl₂, 25 deg C, 2 h, 2.) CH₂Cl₂, MeOH, 25 deg C, 2 h

With chlorodimethylcyclopentadienyltitanium(IV); oxalic acid; potassium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol;

Reference yield:

: 120238-42-8,131472-74-7
methyl (S)-2-(diphenylmethylideneamino)-3-phenylpropanoate

: 152170-23-5
(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) i-Bu₂AlH, i-Bu₃Al / 1.) CH₂Cl₂, toluene, from -73 deg C to -68 deg C, 2.) CH₂Cl₂, toluene, ether, a) -73 deg C, 10 h, b) from -73 deg C to 15 deg C, 4 h

2: 1.) KH / 1.) THF, 25 deg C , 2 h, 2.) THF, from 0 deg C to 25 deg C, 1 h

3: aq. H₂C₂O₄ / methanol; tetrahydrofuran / 3 h / 25 °C

4: 1.) CpTi(CH₃)2Cl / 1.) THF, Et₂O, 25 deg C, 2 h, 2.) THF, Et₂O, 25 deg C, 2 h

5: 2.) NaBH₃CN / 1.) CH₂Cl₂, 25 deg C, 2 h, 2.) CH₂Cl₂, MeOH, 25 deg C, 2 h

With chlorodimethylcyclopentadienyltitanium(IV); triisobutylaluminum; oxalic acid; potassium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol;

Reference yield:

: 111-64-8
n-octanoic acid chloride

: 152170-23-5
(2S,3S,5R)-4-(benzyloxy)-2-(2'-cyano-1'-nonen-1'-yl)-1-methyl-5-(phenylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / acetonitrile / 0.5 h / Heating

2: 1.) CpTi(CH₃)2Cl / 1.) THF, Et₂O, 25 deg C, 2 h, 2.) THF, Et₂O, 25 deg C, 2 h

3: 2.) NaBH₃CN / 1.) CH₂Cl₂, 25 deg C, 2 h, 2.) CH₂Cl₂, MeOH, 25 deg C, 2 h

With chlorodimethylcyclopentadienyltitanium(IV); sodium cyanoborohydride; In acetonitrile;