Technology Process of 6-(tert-butyldiphenylsilyloxy)-2-methylhexane-1,2-diol
There total 7 articles about 6-(tert-butyldiphenylsilyloxy)-2-methylhexane-1,2-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; N-methyl-2-indolinone;
In
1,4-dioxane; water; tert-butyl alcohol;
at 20 ℃;
for 1.5h;
DOI:10.1016/S0040-4020(00)00009-0
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / imidazole / dimethylformamide / 0.67 h / 20 °C
2: 94 percent / m-CPBA / CH2Cl2 / 3 h / 20 °C
3: 98 percent / LiEt3BH / tetrahydrofuran / 1 h / 0 °C
4: 76 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 0 °C
5: 92 percent / Cp2TiCl2 / toluene; tetrahydrofuran / 0.17 h / 20 °C
6: 100 percent / NMO; OsO4 / dioxane; H2O; 2-methyl-propan-2-ol / 1.5 h / 20 °C
With
1H-imidazole; bis(cyclopentadienyl)titanium dichloride; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; lithium triethylborohydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
1: silylation / 2: Epoxidation / 3: Reduction / 4: Swern oxidation / 5: olefination / 6: dihydroxylation;
DOI:10.1016/S0040-4020(00)00009-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 0 °C
2: 92 percent / Cp2TiCl2 / toluene; tetrahydrofuran / 0.17 h / 20 °C
3: 100 percent / NMO; OsO4 / dioxane; H2O; 2-methyl-propan-2-ol / 1.5 h / 20 °C
With
bis(cyclopentadienyl)titanium dichloride; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; tert-butyl alcohol;
1: Swern oxidation / 2: olefination / 3: dihydroxylation;
DOI:10.1016/S0040-4020(00)00009-0
