dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

Base Information

Chemical Name:dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate
CAS No.:86661-25-8
Molecular Formula:C₁₈H₂₁NO₇
Molecular Weight:363.367
Hs Code.:

Synonyms:dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

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Chemical Property of dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

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Technology Process of dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

There total 25 articles about dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 38323-22-7
dimethyl (4-nitrobenzylidene)malonate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 86661-25-8
dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

Guidance literature:: With C₁₅H₂₁N₃O; 3,5-dinitrosalicylic acid; In water; at 35 ℃; for 72h; optical yield given as %ee; stereoselective reaction;
DOI:10.1039/b910939k

Reference yield:

: 38323-22-7
dimethyl (4-nitrobenzylidene)malonate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: dimethyl 2-(4-nitrophenyl)-(2-oxocyclohexyl)methylmalonate

: 86661-25-8
dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

Guidance literature:: With piperidine; (S)-2-((naphthalen-2-ylthio)methyl)pyrrolidine; In ethyl acetate; at 35 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chir.22055

Reference yield:

: 38323-22-7
dimethyl (4-nitrobenzylidene)malonate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: dimethyl 2-((4-nitrophenyl)(2-oxocyclohexyl)methyl)malonate

: 86661-25-8
dimethyl 2‐{(S)‐(4‐nitrophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

Guidance literature:: cyclohexanone; With (S)-2-amino-3-methyl-N-(pyridin-2-yl)butanamide; cobalt perchlorate hexahydrate; In tetrahydrofuran; at 20 ℃; for 3h;

dimethyl (4-nitrobenzylidene)malonate; In tetrahydrofuran; at 20 ℃; for 96h; Overall yield = 64 %Spectr.; enantioselective reaction;
DOI:10.1021/jo301070s