2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

Base Information

Chemical Name:2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone
CAS No.:1262512-38-8
Molecular Formula:C₁₇H₁₅ClN₂O₂
Molecular Weight:314.771
Hs Code.:

Synonyms:2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

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Chemical Property of 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

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Technology Process of 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

There total 4 articles about 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1262512-36-6
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-cyclopentane-1,3-dione

: 77-78-1
dimethyl sulfate

: 1262512-38-8
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

Guidance literature:: 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-cyclopentane-1,3-dione; With potassium carbonate; In acetone; at 20 ℃; for 0.0833333h;

dimethyl sulfate; In acetone; for 3h; Reflux;

Reference yield:

: 115297-57-9
4-chlorobenzene-1-carboximidamide hydrogeniodide

: 1262512-38-8
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; sodium / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

1.3: pH 1

2.1: trichlorophosphate / 2 h / Reflux

3.1: potassium phosphate / palladium diacetate; XPhos / 1,4-dioxane / 0.5 h / 150 °C / microwave irradiation

4.1: potassium carbonate / acetone / 0.08 h / 20 °C

4.2: 3 h / Reflux

With potassium phosphate; ethanol; sodium; potassium carbonate; trichlorophosphate; palladium diacetate; XPhos; In 1,4-dioxane; acetone;

Reference yield:

: 180606-47-7
2-(4-chloro-phenyl)-5-methyl-3H-pyrimidin-4-one

: 1262512-38-8
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-3-methoxy-cyclopent-2-enone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 2 h / Reflux

2.1: potassium phosphate / palladium diacetate; XPhos / 1,4-dioxane / 0.5 h / 150 °C / microwave irradiation

3.1: potassium carbonate / acetone / 0.08 h / 20 °C

3.2: 3 h / Reflux

With potassium phosphate; potassium carbonate; trichlorophosphate; palladium diacetate; XPhos; In 1,4-dioxane; acetone;