Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2

Base Information

• Chemical Name: Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2
• CAS No.: 1217266-35-7
• Molecular Formula: C₄₉H₈₆N₁₈O₁₂
• Molecular Weight: 1119.34
• Mol file: 1217266-35-7.mol

Synonyms:Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2

Chemical Property of Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2

There total 1 articles about Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-Fmoc-Arg(NG-pbf)-Rink amide resin + Nα-(9-fluorenylmethyloxycarbonyl)-azido-L-ornithine (1097192-04-5,1176270-25-9) + 2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}-7-octynoic acid (1097192-06-7) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Leu-OH (35661-60-0) + acetic anhydride (108-24-7) + Fmoc-Ile-OH (71989-23-6,251316-98-0) + N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) + N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine (71989-20-3) + N-2,N-6-bis(9-fluorenylmethyloxycarbonyl)-L-lysine (75932-02-4,78081-87-5) → Nα-Ac-Lys-Gly-Nva(δ-N3)-Ser-Ile-Gln-Nle(δ-yl)-Leu-Arg-NH2 (1217266-35-7)

Guidance literature:

Nα-Fmoc-Arg(NG-pbf)-Rink amide resin; With piperidine; In N,N-dimethyl-formamide; for 0.416667h; Automated synthesizer;

Fmoc-Leu-OH; With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; for 0.666667h; Automated synthesizer;

N^α-(9-fluorenylmethyloxycarbonyl)-azido-L-ornithine; 2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}-7-octynoic acid; N-(fluoren-9-ylmethoxycarbonyl)glycine; acetic anhydride; Fmoc-Ile-OH; N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine; N₂-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine; N-2,N-6-bis(9-fluorenylmethyloxycarbonyl)-L-lysine; Further stages;

DOI:10.1002/ejoc.200901157

upstream raw materials:

N^α-(9-fluorenylmethyloxycarbonyl)-azido-L-ornithine

2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}-7-octynoic acid

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Leu-OH