5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

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Chemical Name:5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
CAS No.:1616628-87-5
Molecular Formula:C₂₉H₃₂N₆O₃
Molecular Weight:512.611
Hs Code.:

Synonyms:5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

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Chemical Property of 5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

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Technology Process of 5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

There total 10 articles about 5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1240322-41-1
ND₀₁₁₈

: 1616628-87-5
5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Guidance literature:: With water; potassium hydroxide; In methanol; at 65 ℃; for 18h;

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1616628-87-5
5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 4 h / Reflux

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

4: potassium hydroxide; water / methanol / 18 h / 65 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1616628-87-5
5-{(2-methyl-5-[4-((4-methylpiperazin-1-yl)methyl)benzoylamino]benzyl)amino}-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / Reflux; Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 4 h / Reflux

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

4: potassium hydroxide; water / methanol / 18 h / 65 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;