Technology Process of tert-butyl 5-(benzyloxy)-2-iodobenzoate
There total 1 articles about tert-butyl 5-(benzyloxy)-2-iodobenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 14h;
DOI:10.1021/jo062083t
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate;
tris(dibenzylideneacetone)dipalladium (0);
In
toluene;
for 14h;
Heating;
DOI:10.1021/jo062083t
- Guidance literature:
-
Multi-step reaction with 5 steps
1: K3PO4; 2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl / Pd2(dba)3
2: trifluoroacetic acid
3: oxalyl chloride / dimethylformamide; CH2Cl2 / 5 h / 20 °C
4: triethylamine / CH2Cl2 / 14 h / 20 °C
5: hydrogen / palladium on carbon / ethyl acetate / 14 h / 760.05 Torr
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; oxalyl dichloride; hydrogen; triethylamine; trifluoroacetic acid;
palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium (0);
In
dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1: Suzuki coupling;
DOI:10.1021/jo062083t
