ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate

Base Information

• Chemical Name: ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate
• CAS No.: 1352440-64-2
• Molecular Formula: C₂₂H₂₅FN₂O₅
• Molecular Weight: 416.449
• Mol file: 1352440-64-2.mol

Synonyms:ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate

Chemical Property of ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate

There total 3 articles about ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

ethyl 6-(chloroformyl)hexanoate (14794-32-2) + C13H11FN2O2 (1352440-63-1) → ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate (1352440-64-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Cooling with ice;

DOI:10.1016/j.bmc.2012.05.034

Reference yield:

N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide (73454-93-0) → ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate (1352440-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

1.2: pH 10 / Saturated solution

2.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

With iron; acetic acid; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2012.05.034

Reference yield:

5-nitrosalicylic acid (96-97-9) → ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate (1352440-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenyl phosphite / toluene / 8 h / Reflux

2.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

2.2: pH 10 / Saturated solution

3.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

With triphenyl phosphite; iron; acetic acid; triethylamine; In tetrahydrofuran; ethanol; toluene;

DOI:10.1016/j.bmc.2012.05.034

upstream raw materials:

ethyl 6-(chloroformyl)hexanoate

C₁₃H₁₁FN₂O₂

N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide

5-nitrosalicylic acid

Downstream raw materials:

N-(3-fluorophenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido) benzamide