N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide

Base Information

• Chemical Name: N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide
• CAS No.: 73454-93-0
• Molecular Formula: C₁₃H₉FN₂O₄
• Molecular Weight: 276.224
• Mol file: 73454-93-0.mol

Synonyms:N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide

Chemical Property of N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide

There total 1 articles about N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

meta-fluoroaniline (372-19-0) + 5-nitrosalicylic acid (96-97-9) → N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide (73454-93-0)

Guidance literature:

With triphenyl phosphite; In toluene; for 8h; Reflux;

DOI:10.1016/j.bmc.2012.05.034

Reference yield:

N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide (73454-93-0) → C13H11FN2O2 (1352440-63-1)

Guidance literature:

N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide; With iron; acetic acid; In tetrahydrofuran; ethanol; for 7h; Reflux;

With sodium carbonate; pH=10; Saturated solution;

DOI:10.1016/j.bmc.2012.05.034

Reference yield:

N-(3-fluorophenyl)-2-hydroxy-5-nitrobenzamide (73454-93-0) → N-(3-fluorophenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido) benzamide (1352440-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

1.2: pH 10 / Saturated solution

2.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / Cooling with ice

With hydroxylamine hydrochloride; iron; acetic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol;

DOI:10.1016/j.bmc.2012.05.034

upstream raw materials:

meta-fluoroaniline

5-nitrosalicylic acid

Downstream raw materials:

ethyl 7-[4-hydroxy-3-(N-3-fluorophenylcarbamoyl)phenylamino]-7-oxoheptanoate

N-(3-fluorophenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido) benzamide

C₁₃H₁₁FN₂O₂