(R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

Base Information

Chemical Name:(R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)
CAS No.:355386-68-4
Molecular Formula:C₂₂H₂₇N₃O₂S
Molecular Weight:397.541
Hs Code.:

Synonyms:(R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

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Chemical Property of (R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

Chemical Property:

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Technology Process of (R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

There total 3 articles about (R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

methanolic ammonia: methanolic ammonia

: 355385-64-7
(R)-N-(1-azabicyclo[2.2.2]oct-3-yl)(5-(3-chlorophenyl)thiophene-2-carboxamide)

: 76144-87-1,76189-55-4,76189-56-5,136655-44-2,98327-87-8
2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl

: 355386-68-4
(R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

Guidance literature:: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5
(3R)-quinuclidin-3-amine dihydrochloride

: 355386-68-4
(R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: sodium carbonate / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / tetrahydrofuran; ethanol; water

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; methanol; diethyl ether

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 7311-63-9
5-bromothiophene-2-carboxylic acid

: 355386-68-4
(R)-N-(1-Aza-bicyclo[2.2.2]oct-3-yl)(5-(3-(4-morpholinyl)phenyl)thiophene-2-carboxamide)

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: sodium carbonate / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / tetrahydrofuran; ethanol; water

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; methanol; diethyl ether

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;