6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

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Chemical Name:6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide
CAS No.:936841-66-6
Molecular Formula:C₂₇H₃₂N₂O₄S
Molecular Weight:480.628
Hs Code.:

Synonyms:6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

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Chemical Property of 6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

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Technology Process of 6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

There total 6 articles about 6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 936841-64-4
6-(N,N-diethylcarboxamido)-5-iodo-2-methoxy-N-(2-phenylpropan-2-yl)benzenesulfonamide

: 98-80-6
phenylboronic acid

: 936841-66-6
6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 24h;
DOI:10.1021/jo062385v

Reference yield:

: 936841-26-8
6-(N,N-diethylcarboxamido)-2-methoxy-N-(2-phenylpropan-2-yl)benzenesulfonamide

: 936841-66-6
6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C

1.2: 62 percent / I₂ / tetrahydrofuran / -78 - 20 °C

2.1: 82 percent / Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 24 h / 90 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2.1: Suzuki coupling;
DOI:10.1021/jo062385v

Reference yield:

: 32366-26-0
cumyl azide

: 936841-66-6
6-(N,N-diethylcarboxamido)-2-methoxy-5-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 19.8 g / H₂ / Lindlar's catalyst / ethanol / 12 h

2.1: 50 percent / Et₃N / CH₂Cl₂ / 0 °C

3.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / 0 °C

3.2: 75 percent / tetrahydrofuran / -78 - 20 °C

4.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C

4.2: 62 percent / I₂ / tetrahydrofuran / -78 - 20 °C

5.1: 82 percent / Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 24 h / 90 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sodium carbonate; triethylamine; Lindlar's catalyst; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 5.1: Suzuki coupling;
DOI:10.1021/jo062385v