6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

Base Information

Chemical Name:6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide
CAS No.:1380281-45-7
Molecular Formula:C₂₈H₂₆F₂N₆O₂
Molecular Weight:516.55
Hs Code.:

Synonyms:6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

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Chemical Property of 6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

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Technology Process of 6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

There total 12 articles about 6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 75-44-5
phosgene

: 1380281-70-8
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-(2,4-difluorophenyl)nicotinamide

: 1380281-45-7
6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

Guidance literature:: phosgene; 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-(2,4-difluorophenyl)nicotinamide; In toluene; at 60 ℃; for 20h;

With ammonia; In methanol; toluene;

Reference yield:

: 65515-28-8
methyl 2,6-dichloronicotinate

: 1380281-45-7
6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 18 h / 75 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h

5: toluene / 20 h / 60 °C

With sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,1'-carbonyldiimidazole; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; toluene; 2: Suzuki Coupling;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1380281-45-7
6-{1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]ureido}-2-(2,4-difluorophenyl)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 80 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 18 h / 75 °C

4: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C

5: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h

6: toluene / 20 h / 60 °C

With sulfuric acid; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,1'-carbonyldiimidazole; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; toluene; 3: Suzuki Coupling;