1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

Base Information

Chemical Name:1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate
CAS No.:1442472-61-8
Molecular Formula:CH₄O₃S*C₂₇H₂₈FN₅O₃
Molecular Weight:585.656
Hs Code.:

Synonyms:1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

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Chemical Property of 1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

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Technology Process of 1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

There total 13 articles about 1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1442472-59-4
1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

: 1442472-61-8
1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

Guidance literature:: With methanesulfonic acid; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 959163-01-0
6-chloro-4-ethylamino-pyridine-3-carbaldehyde

: 1442472-61-8
1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

2: 1,4-dioxane / 40 h / 100 °C

3: ethyl acetate / 16 h / 20 °C

4: methanesulfonic acid / acetonitrile / 1 h / 20 °C

With aluminum oxide; potassium fluoride; methanesulfonic acid; In 1,4-dioxane; N,N-dimethyl acetamide; ethyl acetate; acetonitrile;

Reference yield:

: 1012880-04-4
ethyl 2-(4-fluoro-2-methyl-5-nitrophenyl)acetate

: 1442472-61-8
1-(5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 2660.18 Torr

2: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

3: 1,4-dioxane / 40 h / 100 °C

4: ethyl acetate / 16 h / 20 °C

5: methanesulfonic acid / acetonitrile / 1 h / 20 °C

With aluminum oxide; potassium fluoride; methanesulfonic acid; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; ethyl acetate; acetonitrile;