2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Base Information

Chemical Name:2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole
CAS No.:727718-93-6
Molecular Formula:C₂₂H₂₂ClN₉
Molecular Weight:447.93
Hs Code.:

Synonyms:2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Suppliers and Price of 2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 23 raw suppliers

Chemical Property of 2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Chemical Property:

Melting Point:>139°C (dec.)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Losartan is a medication used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement.Losartan was patented in 1986, and approved for medical use in the United States in 1995. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.Losartan was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.
Uses Losartan Azide is an impurity of Losartan (L470470). Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Technology Process of 2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

There total 4 articles about 2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-(1-(triphenylmethyl))tetrazol-5-yl)biphenyl-4-yl)methyl]-1H-imidazole

: 727718-93-6
2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; water; at 22 ℃; for 24h;
DOI:10.3390/molecules25081872

Reference yield:

: 114798-26-4
lorsartan

: 727718-93-6
2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Guidance literature:: With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

Reference yield:

: 124750-99-8
cozaar

: 727718-93-6
2-butyl-4-chloro-5-(azidomethyl)-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl]-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 21 h / 20 °C

2: diphenyl phosphoryl azide / tetrahydrofuran / 20 h / 20 °C

3: hydrogenchloride / water; methanol; 1,4-dioxane / 24 h / 22 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.3390/molecules25081872