6-o-Desmethyldonepezil

Base Information

Chemical Name:6-o-Desmethyldonepezil
CAS No.:120013-56-1
Molecular Formula:C23H27 N O3
Molecular Weight:365.472
Hs Code.:
UNII:556XXE4I5F
DSSTox Substance ID:DTXSID60561627
Metabolomics Workbench ID:42545
Nikkaji Number:J1.010.441F
Wikidata:Q27261288
Mol file:120013-56-1.mol

Synonyms:6-O-desmethyl donepezil

Suppliers and Price of 6-o-Desmethyldonepezil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
6-O-Desmethyl Donepezil
2.5mg
$ 638.00

TRC
6-O-DesmethylDonepezil
2.5mg
$ 320.00

TRC
6-O-DesmethylDonepezil
1mg
$ 145.00

Cayman Chemical
6-O-desmethyl Donepezil
1mg
$ 133.00

Cayman Chemical
6-O-desmethyl Donepezil
500μg
$ 95.00

Cayman Chemical
6-O-desmethyl Donepezil
5mg
$ 570.00

Biosynth Carbosynth
6-O-Desmethyl donepezil
5 mg
$ 656.30

Biosynth Carbosynth
6-O-Desmethyl donepezil
1 mg
$ 204.80

Biosynth Carbosynth
6-O-Desmethyl donepezil
2 mg
$ 325.50

Biosynth Carbosynth
6-O-Desmethyl donepezil
25 mg
$ 1969.00

Total 10 raw suppliers

Chemical Property of 6-o-Desmethyldonepezil

Chemical Property:

Melting Point:57-59掳C
Boiling Point:545.3±50.0 °C(Predicted)
PKA:9.46±0.40(Predicted)
PSA：49.77000
Density:1.190±0.06 g/cm3(Predicted)
LogP:3.99600
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Dichloromethane, Methanol (Slightly)
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:365.19909372
Heavy Atom Count:27
Complexity:496

Purity/Quality:

95% ^*data from raw suppliers

6-O-Desmethyl Donepezil ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)O
Uses A metabolite of Donepezil, an inhibitor of acetylcholinesterase A metabolite of Donepezil (D531750), an inhibitor of acetylcholinesterase.

Technology Process of 6-o-Desmethyldonepezil

There total 8 articles about 6-o-Desmethyldonepezil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (E)-2-((1-benzylpiperidin-4-yl)methylene)-6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one

: 120013-56-1
O₆-Demethyl-Donepezil

Guidance literature:: With methyl-phenyl-thioether; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃;
DOI:10.3390/molecules23123252

Reference yield: 94.0%

: (Z)-2-((1-benzylpiperidin-4-yl)methylene)-6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one

: 120013-56-1
O₆-Demethyl-Donepezil

Guidance literature:: With methyl-phenyl-thioether; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; Sealed tube;
DOI:10.3390/molecules25010077