N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide
CAS No.:1401449-68-0
Molecular Formula:C₂₇H₂₄F₄N₄O₂
Molecular Weight:512.507
Hs Code.:

Synonyms:N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

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Chemical Property of N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

There total 11 articles about N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 372-20-3
3-fluorophenol

: 1401449-62-4
4-{6-bromo-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-N-cyclopropyl-2-methylbenzamide

: 1401449-68-0
N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: With dimethylaminoacetic acid; caesium carbonate; copper(l) chloride; In 1,4-dioxane; at 110 ℃; for 3.5h; Microwave irradiation;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1401449-68-0
N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 6 h / Reflux

3: sodium periodate; ammonium acetate / water; acetone / 20 - 40 °C

4: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 48 h / 23 °C

5: caesium carbonate; copper(l) chloride; dimethylaminoacetic acid / 1,4-dioxane / 3.5 h / 110 °C / Microwave irradiation

With pyridine; pyridine N-oxide; sodium periodate; dimethylaminoacetic acid; ammonium acetate; copper diacetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(l) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; water; acetone;

Reference yield:

: 345965-99-3
4-bromo-N-cyclopropyl-2-methylbenzamide

: 1401449-68-0
N-cyclopropyl-4-{6-(3-fluorophenoxy)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 6 h / Reflux

2: sodium periodate; ammonium acetate / water; acetone / 20 - 40 °C

3: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 48 h / 23 °C

4: caesium carbonate; copper(l) chloride; dimethylaminoacetic acid / 1,4-dioxane / 3.5 h / 110 °C / Microwave irradiation

With pyridine; pyridine N-oxide; sodium periodate; dimethylaminoacetic acid; ammonium acetate; copper diacetate; caesium carbonate; copper(l) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; water; acetone;