(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

Base Information

Chemical Name:(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate
CAS No.:1291083-48-1
Molecular Formula:C₂₂H₃₇NO₄Si
Molecular Weight:407.626
Hs Code.:

Synonyms:(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

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Chemical Property of (R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

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Technology Process of (R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

There total 5 articles about (R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4248-19-5
tert-butyl carbazate

: 5-(tert-butyldimethylsilyloxy)-1-diazo-1-phenylpentan-2-one

: 1291083-48-1
(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

Guidance literature:: With tetrakis(trifluoroacetato)rhodium(II); C₄₁H₃₁O₄P; In chloroform; at 25 ℃; for 0.0166667h; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.201400236

Reference yield: 68.0%

: tert-butyl 5-(tert-butyldimethylsilyloxy)-2-nitro-1-phenylpentylcarbamate

: 1291083-48-1
(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

Guidance literature:: With sodium nitrite; In water; N,N-dimethyl-formamide; at 45 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.031

Reference yield:

: 271600-36-3
N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide

: 1291083-48-1
(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: cesiumhydroxide monohydrate; N-benzyl quinidinium chloride / toluene / 40 h / -55 °C / Inert atmosphere

2: sodium nitrite / water; N,N-dimethyl-formamide / 12 h / 45 °C / Inert atmosphere

With N-benzyl quinidinium chloride; cesiumhydroxide monohydrate; sodium nitrite; In water; N,N-dimethyl-formamide; toluene; 1: aza-Henry reaction;
DOI:10.1016/j.tet.2011.02.031