tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate
CAS No.:1291083-50-5
Molecular Formula:C₃₁H₄₃F₆NO₄Si
Molecular Weight:635.763
Hs Code.:

Synonyms:tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Suppliers and Price of tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

There total 5 articles about tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1291083-49-2
tert-butyl (1R,2R)-5-(tert-butyldimethylsilyloxy)-2-hydroxy-1-phenylpentylcarbamate

: 32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide

: 1291083-50-5
tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.583333h; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.031

Reference yield:

: tert-butyl 5-(tert-butyldimethylsilyloxy)-2-nitro-1-phenylpentylcarbamate

: 1291083-50-5
tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite / water; N,N-dimethyl-formamide / 12 h / 45 °C / Inert atmosphere

2: sodium tetrahydroborate; cerium(III) chloride heptahydrate / ethanol; dichloromethane / 7 h / -78 - -40 °C / Inert atmosphere

3: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium nitrite; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.02.031

Reference yield:

: 1291083-48-1
(R)-(-)-tert-butyl 5-(tert-butyldimethylsilyloxy)-2-oxo-1-phenylpentylcarbamate

: 1291083-50-5
tert-butyl (1R,2R)-2-(3,5-bis(trifluoromethyl)benzyloxy)-5-(tert-butyldimethylsilyloxy)-1-phenylpentylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / ethanol; dichloromethane / 7 h / -78 - -40 °C / Inert atmosphere

2: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetra-(n-butyl)ammonium iodide; sodium hydride; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.02.031