2-Cyclopropylquinoline-4-carbohydrazide

Base Information

• Chemical Name: 2-Cyclopropylquinoline-4-carbohydrazide
• CAS No.: 119778-68-6
• Molecular Formula: C₁₃H₁₃N₃O
• Molecular Weight: 227.266
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID60402086
• Mol file: 119778-68-6.mol

Synonyms:2-cyclopropylquinoline-4-carbohydrazide;119778-68-6;Oprea1_616494;DTXSID60402086;BBL013897;MFCD00178250;STK409477;AKOS003245414;SB86365;LS-01204;CS-0207805;2-Cyclopropyl-quinoline-4-carboxylic acid hydrazide

Chemical Property of 2-Cyclopropylquinoline-4-carbohydrazide

Chemical Property:

• Refractive Index: 1.702
• PSA: 68.01000
• Density: 1.319g/cm³
• LogP: 2.80690
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 227.105862047
• Heavy Atom Count: 17
• Complexity: 303

Purity/Quality:

97% ^*data from raw suppliers

2-Cyclopropylquinoline-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2)C(=O)NN

Technology Process of 2-Cyclopropylquinoline-4-carbohydrazide

There total 4 articles about 2-Cyclopropylquinoline-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Cyclopropyl-4-ethoxycarbonylquinoline (119778-66-4) → 2-Cyclopropyl-4-hydrazidoquinoline (119778-68-6)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1007/BF00771640

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → 2-Cyclopropyl-4-hydrazidoquinoline (119778-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / KOH / aq. ethanol / 7 h / Heating

2: 52 percent / conc. H₂SO₄ / Heating

3: 84 percent / 85percent hydrazine hydrate / ethanol / Heating

With potassium hydroxide; sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1007/BF00771640

Reference yield:

2-Cyclopropyl-4-carboxyquinoline (119778-64-2) → 2-Cyclopropyl-4-hydrazidoquinoline (119778-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / conc. H₂SO₄ / Heating

2: 84 percent / 85percent hydrazine hydrate / ethanol / Heating

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1007/BF00771640

upstream raw materials:

2-Cyclopropyl-4-ethoxycarbonylquinoline

Cyclopropyl methyl ketone

2-Cyclopropyl-4-carboxyquinoline

indole-2,3-dione

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