C₂₂H₁₇N₃O

Base Information

• Chemical Name: C₂₂H₁₇N₃O
• CAS No.: 1609244-11-2
• Molecular Formula: C₂₂H₁₇N₃O
• Molecular Weight: 339.396
• Mol file: 1609244-11-2.mol

Synonyms:C₂₂H₁₇N₃O

Chemical Property of C₂₂H₁₇N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₁₇N₃O

There total 2 articles about C₂₂H₁₇N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C17H13F3O4S (1609244-37-2) + 2-(2-azidophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1579291-74-9) → C22H17N3O (1609244-11-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; at 80 ℃; for 0.25h; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201308611

Reference yield:

1,3-diphenyl-2-methylpropane-1,3-dione (1846-29-3) → C22H17N3O (1609244-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / dichloromethane / 2 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane / 0.25 h / 80 °C / Glovebox; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium hydrogencarbonate; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1002/anie.201308611

Reference yield: 87.0%

C22H17N3O (1609244-11-2) → N-benzoyl-2-methyl-3-phenylindole (102451-98-9)

Guidance literature:

With [Rh₂(a,a,a’,a’-tetramethyl-1,3-benzenedipropionic acid)₂]; In toluene; at 130 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201308611

upstream raw materials:

1,3-diphenyl-2-methylpropane-1,3-dione

C₁₇H₁₃F₃O₄S

2-(2-azidophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

N-benzoyl-2-methyl-3-phenylindole

N-acetyl-2,3-dimethylindole