Technology Process of methyl (2E)-3-(4-{[(benzyloxy)carbonyl]amino}phenyl)acrylate
There total 1 articles about methyl (2E)-3-(4-{[(benzyloxy)carbonyl]amino}phenyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
1.2: tetrahydrofuran / 5 h / -78 - 20 °C
2.1: NaH / dimethylformamide / 0.33 h / 0 °C
2.2: 89 percent / dimethylformamide / 15 h / 0 - 20 °C
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol050730h
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -78 - -20 ℃;
DOI:10.1021/ol050730h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 52 percent / LiAlH4 / tetrahydrofuran / -78 - -20 °C
2.1: Me2CH=C(Cl)NMe2 / CH2Cl2 / 0.67 h / 23 °C
2.2: N,N-dimethylaniline; Et3N / CH2Cl2 / 0 - 20 °C
3.1: bis(N-t-butylsalicylaldiminato)copper(II) / 1,2-dichloro-ethane; toluene / Heating
4.1: LiBH4 / tetrahydrofuran / 0 - 20 °C
5.1: Et3N / CH2Cl2 / 0 - 20 °C
6.1: Na2S / dimethylsulfoxide / 20 °C
With
sodium sulfide; lithium aluminium tetrahydride; lithium borohydride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine;
bis(N-tert-butylsalicylaldiminato)copper(II);
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ol050730h