tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate
CAS No.:461052-66-4
Molecular Formula:C₃₄H₄₆N₄O₇S
Molecular Weight:654.828
Hs Code.:

Synonyms:tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

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Chemical Property of tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

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Technology Process of tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

There total 7 articles about tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 461052-64-2
3-{2-[1-(3-piperidin-4-yl-propyl)-1H-indol-3-yl]-acetylamino}-2-(toluene-4-sulfonylamino)-propionic acid methyl ester

: 461052-66-4
tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Guidance literature:: With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 24h;
DOI:10.1016/S0223-5234(01)01325-3

Reference yield:

: 1912-33-0
Indole-3-acetic acid methyl ester

: 461052-66-4
tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / NaH / dimethylformamide / 20 °C

2: 80 percent / aq. LiOH / methanol / 20 °C

3: 70 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / CH₂Cl₂ / 24 h / 20 °C

4: 71 percent / H₂ / 10 percent Pd/C / methanol / 20 °C / 760 Torr

5: 90 percent / Et₃N / H₂O; dioxane / 24 h / 20 °C

With dmap; lithium hydroxide; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(01)01325-3

Reference yield:

: 99198-80-8
benzyl 4-(2-hydroxypropyl)-1-piperidinecarboxylate

: 461052-66-4
tert-butyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxopropyl)amino]-2-oxo-ethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / triphenylphosphine; imidazole; iodine / toluene; acetonitrile / 3 h / 20 °C

2: 55 percent / NaH / dimethylformamide / 20 °C

3: 80 percent / aq. LiOH / methanol / 20 °C

4: 70 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / CH₂Cl₂ / 24 h / 20 °C

5: 71 percent / H₂ / 10 percent Pd/C / methanol / 20 °C / 760 Torr

6: 90 percent / Et₃N / H₂O; dioxane / 24 h / 20 °C

With 1H-imidazole; dmap; lithium hydroxide; hydrogen; iodine; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0223-5234(01)01325-3