Technology Process of methyl 3-(3-iodoimidazo[1,2-b]pyridazin-7-yl)benzoate
There total 6 articles about methyl 3-(3-iodoimidazo[1,2-b]pyridazin-7-yl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-iodo-succinimide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 110 °C / Inert atmosphere
2: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 20 °C
3: isopropyl alcohol; water / 4 h / 100 °C
4: N-iodo-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C
With
hydrogenchloride; N-iodo-succinimide; water; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;
palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium carbonate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / 1,4-dioxane; water / 95 °C / Inert atmosphere
2: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 100 °C
3: caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 110 °C / Inert atmosphere
4: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 20 °C
5: isopropyl alcohol; water / 4 h / 100 °C
6: N-iodo-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C
With
hydrogenchloride; N-iodo-succinimide; water; sodium carbonate; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; trichlorophosphate;
di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol;
1: Suzuki Coupling;