methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

Base Information

Chemical Name:methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate
CAS No.:1268383-41-0
Molecular Formula:C₂₇H₂₀F₅N₅O₄
Molecular Weight:573.479
Hs Code.:

Synonyms:methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

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Chemical Property of methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

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Technology Process of methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

There total 18 articles about methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1268385-46-1
2-(2,3-difluorophenyl)-1H-imidazole-4,5-dicarbaldehyde

: bis(1,1-dimethylethyl) 1-(2-(methyloxy)-2-oxo-1-{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}ethyl)-1,2-hydrazinedicarboxylate

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

Guidance literature:: With hydrogen bromide; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo4014595

Reference yield: 54.0%

: 1105058-57-8
2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

: 1268385-35-8
methyl 2-bromo-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 2646-91-5
2,3-difluorobenzaldehyde

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / water; isopropyl alcohol / 6 h / 25 °C / Inert atmosphere; Large scale

2.1: potassium hydroxide / water / 0.17 h / 25 °C / Inert atmosphere; Large scale

2.2: 10 h / 25 - 50 °C / Inert atmosphere; Large scale

3.1: Pt(5%)Bi(5%)/C; sodium hydroxide / water; acetonitrile / 5 h / 23 - 45 °C

4.1: hydrogen bromide / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With Pt(5%)Bi(5%)/C; ammonium acetate; hydrogen bromide; potassium hydroxide; sodium hydroxide; In water; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jo4014595