5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one

Base Information

• Chemical Name: 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one
• CAS No.: 131890-42-1
• Molecular Formula: C₁₄H₁₃N₃O₂S
• Molecular Weight: 287.342

Synonyms:5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one

Chemical Property of 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one

Chemical Property:

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Technology Process of 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one

There total 4 articles about 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

6-(3-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (131890-31-8) + methyl iodide (74-88-4) → 5-carbonitrile-1,6-dihydro-4-(3-methoxyphenyl)-2-(methylthio)-6-oxopyrimidine (128640-73-3) + 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one (131890-42-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/0223-5234(90)90148-V

Reference yield: 75.0%

5-carbonitrile-1,6-dihydro-4-(3-methoxyphenyl)-2-(methylthio)-6-oxopyrimidine (128640-73-3) + methyl iodide (74-88-4) → 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one (131890-42-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1016/0223-5234(90)90148-V

Reference yield: 72.7%

6-(3-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (131890-31-8) + methyl iodide (74-88-4) → 5-cyano-6-(3-methoxyphenyl)-3-methyl-2-methylthio-3,4-dihydropyrimidin-4-one (131890-42-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1016/0223-5234(90)90148-V

upstream raw materials:

6-(3-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

methyl iodide

5-carbonitrile-1,6-dihydro-4-(3-methoxyphenyl)-2-(methylthio)-6-oxopyrimidine

3-methoxy-benzaldehyde

Downstream raw materials:

5-Amino-1-[5-cyano-4-(3-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester

5-cyano-3-methyl-6-(3-methoxyphenyl)-2-piperonalhydrazino-3,4-dihydropyrimidin-4-one

2-(5-Amino-4-cyano-3-methylsulfanyl-pyrazol-1-yl)-1-methyl-6-oxo-4-p-tolyl-1,6-dihydro-pyrimidine-5-carbonitrile

6-cyano-5-(3-methoxyphenyl)-8-methyltetrazolo<1,5-a>pyrimidin-7-one

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