N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide

Base Information

• Chemical Name: N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide
• CAS No.: 796863-50-8
• Molecular Formula: C₂₂H₃₀N₂O₃
• Molecular Weight: 370.492

Synonyms:N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide

Chemical Property of N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide

Chemical Property:

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Technology Process of N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide

There total 1 articles about N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

m-tolyl aldehyde (620-23-5) + 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine (197229-98-4) → N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide (796863-50-8)

Guidance literature:

5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - 0 ℃;

m-tolyl aldehyde; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1021/jm0407658

Reference yield: 92.0%

N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide (796863-50-8) → N-[4-(3-methylbenzoyl)-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide (796863-51-9)

Guidance literature:

With manganese(IV) oxide; In toluene; Heating;

DOI:10.1021/jm0407658

Reference yield: 55.0%

N-[4-[(3-methylphenyl)hydroxymethyl]-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide (796863-50-8) → 3-amino-5-ethyl-6-methyl-4-[(3-methylphenyl)methyl]pyridin-2(1H)-one (248247-00-9)

Guidance literature:

With hydrogenchloride; acetic acid; tin(ll) chloride; at 100 ℃;

DOI:10.1021/jm0407658

upstream raw materials:

m-tolyl aldehyde

5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine

Downstream raw materials:

3-amino-5-ethyl-6-methyl-4-[(3-methylphenyl)methyl]pyridin-2(1H)-one

N-[4-(3-methylbenzoyl)-5-ethyl-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropanamide

3-amino-5-ethyl-6-methyl-4-(3-methylbenzoyl)pyridin-2(1H)-one

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