(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

Base Information

Chemical Name:(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane
CAS No.:240432-02-4
Molecular Formula:C₃₂H₅₀F₂N₂O₄Si₂
Molecular Weight:620.928
Hs Code.:

(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-<N,N'-di(o-fluorobenzoyl)>diaminohexane

Synonyms:(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

Chemical Property:

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Technology Process of (3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

There total 5 articles about (3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 393-52-2
2-Fluorobenzoyl chloride

: 240432-01-3
(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

: 240432-02-4
(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

Guidance literature:: With triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0957-4166(99)00183-4

Reference yield:

: 240431-99-6
(E)-2,2,3,3,12,12,13,13-octamethyl-4,11-dioxa-3,12-disilatetradec-7-ene

: 240432-02-4
(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

Guidance literature:: Multi-step reaction with 5 steps

1: aq. OsO₄, (DHQD)2PHAL, K₃Fe(CN)6, K₂CO₃, CH₃SO₂NH₂ / 2-methyl-propan-2-ol / 19 h / 0 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / NaN₃ / dimethylformamide / 20 h / 100 - 105 °C

4: 97 percent / H₂ / 5 percent Pd/CaCO₃ / ethanol / 5 h / 760 Torr / Ambient temperature

5: 95 percent / Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With osmium(VIII) oxide; sodium azide; methanesulfonamide; hydrogen; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; potassium hexacyanoferrate(III); Lindlar's catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0957-4166(99)00183-4

Reference yield:

: 240432-00-2
(3R,4R)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-dihydroxyhexane

: 240432-02-4
(3S,4S)-1,6-bis(tert-butyldimethylsilyloxy)-3,4-diaminohexane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: 88 percent / NaN₃ / dimethylformamide / 20 h / 100 - 105 °C

3: 97 percent / H₂ / 5 percent Pd/CaCO₃ / ethanol / 5 h / 760 Torr / Ambient temperature

4: 95 percent / Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With sodium azide; hydrogen; triethylamine; Lindlar's catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(99)00183-4