Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

Base Information

Chemical Name:Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate
CAS No.:136604-26-7
Molecular Formula:C₃₁H₃₂N₂O₅
Molecular Weight:512.605
Hs Code.:

Synonyms:Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

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Technology Process of Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

There total 4 articles about Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 21040-45-9
Cinnamyl acetate

: 136583-04-5,136583-24-9
Ethyl N-[2-Nitro-2-(3-phenylprop-2-en-1-yl)acetyl]-L-phenylalaninate

: 136604-26-7
Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; for 10h;
DOI:10.1002/hlca.19910740516

Reference yield:

: 3081-24-1
H-Phe-OEt

: 136604-26-7
Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / TsOH / acetonitrile / 30 - 80 °C

2: 90 percent / HgCl₂ / acetonitrile; H₂O / 30 °C

3: 1) 1,8-diazabicyclo<5.4.0>undec-7-ene, bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / 1) MeCN, 5 min; 2) MeCN, 25-30 deg C, 8-10 h

4: 44 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / acetonitrile / 10 h

With toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; mercury dichloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; acetonitrile;
DOI:10.1002/hlca.19910740516

Reference yield:

: 136583-21-6
N-Nitroacetyl-(S)-phenylalanine ethyl ester

: 136604-26-7
Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 1,8-diazabicyclo<5.4.0>undec-7-ene, bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / 1) MeCN, 5 min; 2) MeCN, 25-30 deg C, 8-10 h

2: 44 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / acetonitrile / 10 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile;
DOI:10.1002/hlca.19910740516