4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

Base Information

Chemical Name:4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide
CAS No.:455927-22-7
Molecular Formula:C₁₈H₁₅ClFN₃OS
Molecular Weight:375.854
Hs Code.:

Synonyms:4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

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Chemical Property of 4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

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Technology Process of 4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

There total 5 articles about 4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 6-methyl-4-(2-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

: 371-40-4
4-fluoroaniline

: 455927-22-7
4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

Guidance literature:: In ethanol; for 5h; Reflux; Inert atmosphere;
DOI:10.1016/j.bioorg.2021.105272

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 455927-22-7
4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / 8 h / Reflux; Inert atmosphere

2: sodium hydroxide / 2 h / Reflux; Inert atmosphere

3: thionyl chloride / 0.67 h / Reflux; Inert atmosphere

4: ethanol / 5 h / Reflux; Inert atmosphere

With hydrogenchloride; thionyl chloride; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.bioorg.2021.105272

Reference yield:

: 301359-45-5
4-(2-chloro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

: 455927-22-7
4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 2 h / Reflux; Inert atmosphere

2: thionyl chloride / 0.67 h / Reflux; Inert atmosphere

3: ethanol / 5 h / Reflux; Inert atmosphere

With thionyl chloride; sodium hydroxide; In ethanol;
DOI:10.1016/j.bioorg.2021.105272