1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

Base Information

Chemical Name:1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester
CAS No.:290812-73-6
Molecular Formula:C₁₅H₂₁N₂O₄P
Molecular Weight:324.317
Hs Code.:

Synonyms:1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

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Chemical Property of 1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

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Technology Process of 1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

There total 3 articles about 1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 290812-73-6
1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / 1,2-dimethoxy-ethane / 0.75 h / -10 °C

1.2: 67 percent / 1,2-dimethoxy-ethane / 17.5 h / -10 - 20 °C

2.1: NaH / toluene / 0.25 h / -78 °C

2.2: 35 percent / NH₂Cl / toluene; diethyl ether / 19 h / -78 - 20 °C

3.1: 61 percent / CH₂Cl₂ / 15 h / -78 - 20 °C

With sodium hydride; In 1,2-dimethoxyethane; dichloromethane; toluene; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Amination / 3.1: Formylation;
DOI:10.1055/s-2000-6315

Reference yield:

: 4484-74-6
4-methylbenzyl iodide

: 290812-73-6
1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / 1,2-dimethoxy-ethane / 0.75 h / -10 °C

1.2: 67 percent / 1,2-dimethoxy-ethane / 17.5 h / -10 - 20 °C

2.1: NaH / toluene / 0.25 h / -78 °C

2.2: 35 percent / NH₂Cl / toluene; diethyl ether / 19 h / -78 - 20 °C

3.1: 61 percent / CH₂Cl₂ / 15 h / -78 - 20 °C

With sodium hydride; In 1,2-dimethoxyethane; dichloromethane; toluene; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Amination / 3.1: Formylation;
DOI:10.1055/s-2000-6315

Reference yield:

: 290812-56-5
1-Cyano-2-(4-methylphenyl)ethylphosphonsaeurediethylester

: 290812-73-6
1-Cyano-1-(formylamido)-2-(4-methylphenyl)ethylphosphonsaeurediethylester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / toluene / 0.25 h / -78 °C

1.2: 35 percent / NH₂Cl / toluene; diethyl ether / 19 h / -78 - 20 °C

2.1: 61 percent / CH₂Cl₂ / 15 h / -78 - 20 °C

With sodium hydride; In dichloromethane; toluene; 1.1: Metallation / 1.2: Amination / 2.1: Formylation;
DOI:10.1055/s-2000-6315