4484-74-6

Basic information

• Product Name: 1-(iodomethyl)-4-methylbenzene
• CAS NO: 4484-74-6
• Molecular Formula: C₈H₉I
• Molecular Weight: 232.0615
• Mol File: 4484-74-6.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 237.5°C at 760 mmHg
• Flash Point: 104.4°C
• Density: 1.647g/cm³
• Vapor Pressure: 0.0689mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 1-(iodomethyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(iodomethyl)-4-methylbenzene(4484-74-6)
• EPA Substance Registry System: 1-(iodomethyl)-4-methylbenzene(4484-74-6)

Safety Data

• Hazardous Substances Data: 4484-74-6(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Odor

Strong, pungent

Usage

Reagent in organic synthesis

Applications

Preparation of pharmaceuticals, fine chemicals, dyes, fragrances, and polymers

Hazard classification

Hazardous substance

Safety precautions

Proper handling and storage required

Upstream product

• 38460-98-9 bis(4-methylbenzyl) ether 
• 104-82-5 4-Methylbenzyl chloride 
• 258339-30-9 tert-butyl-(4-methylbenzyloxy)dimethylsilane 
• 17271-89-5 4-methylphenylmethylazide 
• 93306-62-8 4-methyl-1-(ethoxymethoxy)methyl benzene 
• 92565-77-0 4-methyl-1-(methoxymethoxy)methyl benzene 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 104-84-7 para-methylbenzylamine 
• 76950-85-1 1-(4-Methyl-benzyl)-4,6-diphenyl-1H-pyridine-2-thione 
• 106-42-3 para-xylene 
• 89200-92-0 trimethyl(4-methylbenzyloxy)silane 
• 18484-04-3 2-((4-methylbenzyl)oxy)tetrahydro-2H-pyran 
• 27396-20-9 tert.-Butyl-p-tolylperacetat 
• 76950-78-2 1-(4-Methyl-benzyl)-2-methylsulfanyl-4,6-diphenyl-pyridinium; iodide 

Downstream Products

• 21261-95-0 6-methyl-3-(4-methyl-benzyl)-3H-benzothiazole-2-thione 
• 502610-55-1 diethyl 2-acetyl-2-(4-methylbenzyl)succinate 
• 37859-31-7 2-(4-methylbenzyl)benzo[d]thiazole 
• 136620-24-1 2-(p-tolylmethylsulfanyl)aniline 
• 538-39-6 1,2-di-p-tolylethane 
• 104-87-0 4-methyl-benzaldehyde 
• 99-94-5 p-Toluic acid 
• 38418-10-9 4-methylbenzyl benzoate 

Relevant articles and documents

Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I2

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

Iminophosphorane-mediated regioselective umpolung alkylation reaction of α-iminoesters

Umpolung reactions of imines, especially the asymmetric reactions, have been extensively studied as they provide access to important chiral amines in an efficient manner. The reactions studied range from simple Michael reactions to several kinds of other reactions such as the aza-benzoin reaction, aza-Stetter reaction, addition with MBH carbonate, and Ir-catalysed allylation. Herein, we report the first umpolung alkylation reaction of α-iminoesters with alkyl halides mediated by iminophosphorane as an organic superbase. The desired products were obtained in up to 82% yield with almost perfect regioselectivities. The key to the regioselectivity of this reaction was the use of 4-trifluoromethyl benzyl imines as a substrate. The products were successfully derivatised into the more functionalised molecules in good yields.

Method for efficiently preparing benzyl iodide and derivatives thereof

The invention discloses a method for efficiently preparing benzyl iodide and derivatives thereof. The benzyl iodide and the derivatives thereof are prepared by using a benzaldehyde compound as the initial raw material through complex reaction, main reaction and post-reaction. The method specifically includes: placing rhodium and phosphine ligand into a reaction container, adding an organic solvent, stirring for complexing to obtain a reaction system a, adding iodine, stirring under room temperature, adding the initial material benzaldehyde compound to continuously perform stirring reaction toobtain reaction liquid b, transferring into a high-pressure reaction kettle, performing gas replacement, filling hydrogen, keeping positive pressure, performing reaction under room temperature for 4-48 hours to obtain reaction liquid c, and performing vacuum concentration and column chromatography purification to obtain the target benzyl iodide and the derivatives thereof. The method is cheap in used substrate, simple to operate, good in reaction operation safety, environmentally friendly, high in yield, high in the purity of the benzyl iodide and the derivatives thereof, easy to achieve large-scale production and capable of achieving industrial production to satisfy social medical requirements.