3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

Base Information

Chemical Name:3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid
CAS No.:1263420-05-8
Molecular Formula:C₁₆H₂₀N₄O₃
Molecular Weight:316.36
Hs Code.:

Synonyms:3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

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Chemical Property of 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

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Technology Process of 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

There total 8 articles about 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1263420-04-7
ethyl 3-cyano-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylate

: 1263420-05-8
3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

Guidance literature:: ethyl 3-cyano-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylate; With ammonium hydroxide; dihydrogen peroxide; In ethanol; water; at 20 ℃; for 12h;

With water; sodium hydroxide; In ethanol; at 20 ℃; for 5h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: diethyl 1H-pyrrole-2,5-dicarboxylate

: 1263420-05-8
3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -10 °C

1.2: 17 h / -10 - 20 °C

2.1: hydrogenchloride / ethanol; water / 15 h / Reflux

2.2: 1 h / 80 °C

2.3: pH 1

3.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 1 h / 80 °C

4.1: triethylamine / N,N-dimethyl-formamide / 20 °C

5.1: ammonium hydroxide; dihydrogen peroxide / ethanol; water / 12 h / 20 °C

5.2: 5 h / 20 °C

With hydrogenchloride; ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; N,N-dimethyl-aniline; triethylamine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 779345-31-2
3-cyano-4-hydroxy-pyrrolo[1,2-b]pyridazine-7-carboxylic acid ethyl ester

: 1263420-05-8
3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 1 h / 80 °C

2.1: triethylamine / N,N-dimethyl-formamide / 20 °C

3.1: ammonium hydroxide; dihydrogen peroxide / ethanol; water / 12 h / 20 °C

3.2: 5 h / 20 °C

With ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;