tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

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Chemical Name:tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate
CAS No.:1263420-06-9
Molecular Formula:C₂₀H₂₉N₅O₃
Molecular Weight:387.482
Hs Code.:

Synonyms:tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

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Chemical Property of tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

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Technology Process of tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

There total 8 articles about tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1263420-05-8
3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1263420-06-9
tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; for 5h; Reflux;

Reference yield:

: 7126-50-3
ethyl 5-formyl-1H-pyrrole-2-carboxylate

: 1263420-06-9
tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; potassium permanganate / acetone / 26 h / 20 °C

2.1: sulfuric acid / 36 h / Reflux

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -10 °C

3.2: 17 h / -10 - 20 °C

4.1: hydrogenchloride / ethanol; water / 15 h / Reflux

4.2: 1 h / 80 °C

4.3: pH 1

5.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 1 h / 80 °C

6.1: triethylamine / N,N-dimethyl-formamide / 20 °C

7.1: ammonium hydroxide; dihydrogen peroxide / ethanol; water / 12 h / 20 °C

7.2: 5 h / 20 °C

8.1: triethylamine; diphenyl phosphoryl azide / 5 h / Reflux

With hydrogenchloride; ammonium hydroxide; potassium permanganate; sulfuric acid; diphenyl phosphoryl azide; N-benzyl-N,N,N-triethylammonium chloride; water; dihydrogen peroxide; N,N-dimethyl-aniline; triethylamine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 952569-58-3
5-(ethoxycarbonyl)-1H-pyrrole-2-carboxylic acid

: 1263420-06-9
tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 36 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -10 °C

2.2: 17 h / -10 - 20 °C

3.1: hydrogenchloride / ethanol; water / 15 h / Reflux

3.2: 1 h / 80 °C

3.3: pH 1

4.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 1 h / 80 °C

5.1: triethylamine / N,N-dimethyl-formamide / 20 °C

6.1: ammonium hydroxide; dihydrogen peroxide / ethanol; water / 12 h / 20 °C

6.2: 5 h / 20 °C

7.1: triethylamine; diphenyl phosphoryl azide / 5 h / Reflux

With hydrogenchloride; ammonium hydroxide; sulfuric acid; diphenyl phosphoryl azide; N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; N,N-dimethyl-aniline; triethylamine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;