2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone

Base Information

• Chemical Name: 2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone
• CAS No.: 74746-13-7
• Molecular Formula: C₂₅H₂₅BrO₅
• Molecular Weight: 485.375
• Mol file: 74746-13-7.mol

Synonyms:2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone

Chemical Property of 2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone

There total 1 articles about 2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(2E)-1-(2-bromo-4,5-dimethoxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one (74746-12-6) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 4,4'-Dimethoxybiphenyl (2132-80-1) + 2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone (74746-13-7)

Guidance literature:

With copper(I) bromide; In tetrahydrofuran; for 1h; ice-bath;

Reference yield: 95.0%

2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone (74746-13-7) → 2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)acrylophenone (74746-16-0)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 3h; Heating;

Reference yield:

2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)propiophenone (74746-13-7) → 1,1-bis-(4-methoxyphenyl)ethylene (4356-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone / benzene / 3 h / Heating

2: CF₃COOH

With trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene;

upstream raw materials:

(2E)-1-(2-bromo-4,5-dimethoxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one

4-methoxyphenyl magnesium bromide

Downstream raw materials:

2'-bromo-4',5'-dimethoxy-3,3-bis-(4-methoxyphenyl)acrylophenone

1,1-bis-(4-methoxyphenyl)ethylene