(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride

Base Information

Chemical Name:(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride
CAS No.:334476-35-6
Molecular Formula:C₂₂H₂₂F₇N₃O*ClH
Molecular Weight:513.886
Hs Code.:

Synonyms:(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride

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Technology Process of (2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride

There total 2 articles about (2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 334477-16-6
(1R)-1-phenylethyl (3R)-4-{[{[3,5-bis(trifluoromethyl)phenyl]-methyl}(methyl)amino]carbonyl}-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate

: 334476-35-6
(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]-methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide hydrochloride

Guidance literature:: (1R)-1-phenylethyl (3R)-4-{[{[3,5-bis(trifluoromethyl)phenyl]-methyl}(methyl)amino]carbonyl}-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate; With 5% Pd(II)/C(eggshell); hydrogen; In ethanol; water; for 4h; under 760.051 Torr;

With hydrogenchloride; In diethyl ether; ethanol; water;
DOI:10.1021/jm900023b