imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide

Base Information

Chemical Name:imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide
CAS No.:1000381-56-5
Molecular Formula:C₁₇H₁₄N₆OS
Molecular Weight:350.404
Hs Code.:

Synonyms:imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide

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Chemical Property of imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide

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Technology Process of imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide

There total 2 articles about imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000381-59-8
4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-ylamine

: 530-62-1
1,1'-carbonyldiimidazole

: 1000381-56-5
imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Heating / reflux;

Reference yield:

: 99662-34-7
4-(1H-pyrazol-1-yl)benzaldehyde

: 1000381-56-5
imidazole-1-carboxylic acid [4-methyl-5-(4-pyrazol-1-yl-phenyl)-thiazol-2-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / 18 h / Reflux

2: iron; acetic acid / 2 h / 100 °C

3: pyridine; iodine / 8 h / 80 °C

4: dichloromethane / 5 h / Reflux

With pyridine; ammonium acetate; iodine; iron; acetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2012.07.042